A Recent study has shown that OptiMSM reduces liver toxicity linked to high CBD dosages. Cannabis extract and the methylsulfonylmethane (MSM) works synergistically to increase the production of an antioxidant called glutathione which appears to help mitigate the hepatotoxic effects of high CBD doses.
“MSM is already known to mitigate oxidative stress by increasing glutathione, while we also understand that CBD decreases glutathione,” Igor Koturbash, MD, PhD, Associate Professor at University of Arkansas for Medical Sciences, who led the study, said. “So discovering how CRCE (cannabidiol-rich cannabis extract) and MSM work together to increase glutathione, even beyond what MSM could do on its own, was the most exciting part of this study. Hopefully this will lead to future studies to determine if MSM can be used to prevent or treat toxicity issues that could be caused by high CBD doses.”
While none of the treated groups showed evidence of liver toxicity, both groups receiving the cannabis extract saw significant increases in liver-to-total-body-weight ratio. While this increase alone is not indicative of liver damage, the researchers said that the potential benefit of increased glutathione levels should be considered when taking CBD products.